Scientists Create World's First 3D-Printed Heart Using Patient's Own Cells

Dr. Assaf Shpira looks at a 3D print of heart with human tissue at the University of Tel Aviv

While it remains a far way off, scientists hope one day to be able to produce hearts suitable for transplant into humans as well as patches to regenerate defective hearts.

Then the cells were reprogrammed to become pluripotent stem cells, the extracellular matrix that was processed into a personalized hydrogel that served as the ink for the printer that printed the heart.

On Monday, a team of Tel Aviv University researchers revealed the 3D printed heart that completely matches the immunological, cellular, biochemical and anatomical properties of a human patient.

University of Tel Aviv's Tal Dvir presents his team's 3D-printed heart.

This latest invention represents a major turning point for patients with congestive heart failure (CHF), as heart transplantation is the only definitive treatment for patients in the end-stages of the disease.

The differentiated cells were then mixed with the bio-inks and were used to 3D-print patient-specific, immune-compatible cardiac patches with blood vessels and, subsequently, an entire heart. "Our results demonstrate the potential of our approach for engineering personalized tissue and organ replacement in the future".

He showed a 3D print of a heart with visible vessels; the miniature heart measured less than 3 centimetres in size.

New Palestinian PM Ishtaye sworn in before President Abbas
Shtayyeh was named Palestinian prime minister on March 10, replacing the independent university president Rami Al-Hamdallah. Hamas said in a statement that the new government "resorts to unilateralism and monopoly of power".

World’s largest plane by wingspan lifts off into the history books
He added: "Today's flight furthers our mission to provide a flexible alternative to ground launched systems". Stratolaunch was established in 2011 by Microsoft cofounder Paul Allen, who died in October a year ago .

Pep Guardiola: 'Supernatural' Kevin De Bruyne peaking at the right time
In my experience, footballers can be a lot different than you expect, especially if you really get to know them". What's the story here? "But, unfortunately, that cloud still followed me around for a long time".

Though it's much smaller than a human heart-at only 2.5 centimeters, it's about the size of a rabbit's-the proof-of-concept still contains a fully vascularized structure, complete with its own cells, ventricles and atria.

Although the organ is only the size of a cherry and can not pump blood, experts said its creating is a "major medical breakthrough". However, the rabbit-sized 3D printed heart, a focal point of the study, contains stem-cell derived cardiac-muscle cells (cardoimyocytes, or CMs) and vessel-lining endolthelial cells (ECs).

Previously, only simple tissues - without the blood vessels they need to live and function - had been printed, according to a press release from the university.

"But larger human hearts require the same technology".

"The biocompatibility of engineered materials is crucial to eliminating the risk of implant rejection, which jeopardizes the success of such treatments", Dvir said. The cells are now able to contract, but do not yet have the ability to pump.

"Maybe, in ten years, there will be organ printers in the finest hospitals around the world, and these procedures will be conducted routinely". The paper is co-authored by Nadav Noor, Assaf Shapira, Reuven Edri, Idan Gal, Lior Wertheim and Tal Dvir of Tel Aviv University.

Related News:

  • MI  congressman leads effort requesting aid from CDC over measles outbreaks

    MI congressman leads effort requesting aid from CDC over measles outbreaks

    Toi Te Ora Public Health say five cases of measles have been confirmed in the Bay of Plenty region in the past month. However, people tend to travel into and out of the United States, and measles hasn't been eliminated everywhere.
    Harry and Meghan to keep birth of their baby private

    Harry and Meghan to keep birth of their baby private

    Largely, that has pretty much been respected. "I see all the insane press around her and I think it's very unfair". But it seems that Meghan is determined to regain control, by embracing the media, social media to be more precise.
    Chelsea manager picks out positives from the Liverpool loss: Were there any?

    Chelsea manager picks out positives from the Liverpool loss: Were there any?

    That incident featured in a number of previews for the game. "And by the way, we can finally close the slipping book", said Klopp. Salah seems to be back in form and has now hit the back of the net for the second time in two games.
  • Sudan protesters block attempt to break up sit

    Sudan protesters block attempt to break up sit

    The deputy leader also told the U.S. envoy how the military council would "preserve the security and stability of the country". Footage circulating online shows hundreds of troops outside the military headquarters in Khartoum on Monday.
    God of War director confirms there will be 'no DLC coming'

    God of War director confirms there will be 'no DLC coming'

    If you haven't played Dad Simulator - uh, God of War - yet, you can pick it up on the PlayStation store for just $39.99 . In honor of you, our fans, we're starting a week-long celebration of the one-year anniversary of this God of War .
    Disney reveals launch date of its streaming service, read details

    Disney reveals launch date of its streaming service, read details

    You'll also be able to download content that you can access offline when you're not connected to data or wifi. As with the legacy of the brand, Disney + promises the best in service, quality, and usability.
  • U.S.  lawmakers ask Trump to facilitate inter-Korean economic projects

    U.S. lawmakers ask Trump to facilitate inter-Korean economic projects

    In the months since Hanoi, there have been no known follow-up negotiations between Washington and Pyongyang . Responding to Mr Kim's speech, South Korea repeated its stance of promoting the talks.
    Com breach allowed hackers to read (some) emails for months

    Com breach allowed hackers to read (some) emails for months

    In a blog post from April, Microsoft said that it saw an average of 300,000 phishing attempts in February alone. Microsoft sent a warning to Outlook users detailing a hack that lasted from January 1 to March 28.
    Catholic faithful marks start of Holy Week

    Catholic faithful marks start of Holy Week

    He said: 'Joyful acclamations at Jesus's entrance into Jerusalem, followed by his humiliation. Peter's Square, which is jammed with tens of thousands of faithful.
  • 3 killed after small plane collides with helicopter in Nepal

    3 killed after small plane collides with helicopter in Nepal

    In 2008, another Twin Otter plane carrying 16 passengers and three crew crashed shortly before it was due to land at Lukla. The airport is often referred to as the world's most unsafe because of the short runway and hard approach.
    New York City to yeshivahs

    New York City to yeshivahs

    The National Institutes of Health says reports of serious reactions to vaccines are rare: about one in every 100,000 vaccinations. The two-dose MMR is typically administered after a child's first birthday, given again as children prepare to go to school.
    See Hayden Christensen & Matt Lanter Unite At Star Wars Celebration

    See Hayden Christensen & Matt Lanter Unite At Star Wars Celebration

    When asked how The Mandalorian would be different from other Star Wars properties, Filoni was hesitant to get into details. We also saw footage of Carano pulling off some great stunts, and a line from Breaking Bad alum Giancarlo Esposito .


Most liked

Global measles cases up by 300 percent in 2019
It is one of the most contagious viruses around, however, nothing about measles has changed. Of the 329 confirmed NY measles cases, 284 are children and 45 are adults.

Yogi Adityanath, Mayawati censured, barred from campaigning for 72, 48 hours respectively
During the hearing, the bench asked the counsel for EC as to what action they have taken against Mayawati and Yogi Adityanath for alleged hate speeches.

DC police: Eagles’ Mills, Wiz’s Robinson arrested for fight
Robinson likely won't be playing with the Wizards next season, according to a Saturday news release from the team. Robinson, who is 6-foot-8, was reportedly taken to the hospital after the incident.

Pelicans hire Griffin as President, Basketball Operations
The former Cavaliers general manager's first order of business presumably will be trading Anthony Davis . David Griffin will be the man charged with getting the best possible return for Anthony Davis .

Trump says Tiger Woods to get Presidential Medal of Freedom
Trump owns a dozen golf courses in the US and frequently spends his weekends at his clubs in Florida, Virginia or New Jersey. Woods' win, which was his first major title victory since 2008, marked a major career comeback for the 43-year-old.

Ex-Venezuelan general detained in Spain on USA warrant
In May 2013, a Florida court accused him of having worked for Colombian drug traffickers from 2004 to 2010. Spanish police arrested Carvajal on April 12 on a USA drug-trafficking warrant.

Israel Folau sacked over homophobic social media post
When asked if he regretted the post, Folau maintained his stance, although he insisted that he shared the message "with love". Israel Folau has officially been issued a breach notice over his inflammatory social media posts last week.

Massive Fire Breaks Out at Notre Dame Cathedral in Paris
The severity of the fire is not yet fully determined, but firefighters indicated that the it began in the attic of the cathedral. Mayor of Paris Anne Hidalgo labelled the fire "terrible" despite the extent of the damage being unclear at this stage.

Deadly storms leave thousands without power in eastern U.S
The threat of severe weather will likely increase throughout the day, the National Weather Service's Storm Prediction Center said. Deadly storms continue to move across the South after spawning suspected tornadoes and damaging several homes.

Environmental activists block central London roads
The group says that it intends to "bring London to a standstill for up to two weeks". Police said three men were arrested in the ongoing protests.

'When Calls the Heart' renewed for Season 7
Loughlin and Giannulli have not entered a plea nor indicated that they are preparing to do so. Huffman is scheduled to appear in Boston's federal court on May 24 to enter her plea.

Ecuador's president says Assange tried to use its embassy to spy
More than 70 British legislators have urged Javid to give priority to a case involving rape allegations ahead of the U.S. request. Julian Assange , dressed in a vest and shorts, skateboards around his bedroom in the Ecuadorian embassy.

Big Little Lies Season 2 Trailer Welcomes Meryl Streep To HBO Drama
Big Little Lies will return to fill the summer Sunday void left behind by Game of Thrones . Douglas Smith , Poorna Jagannathan and Denis O'Hare will also appear in the new season.

Xbox One S All Digital launches tomorrow, says report
Microsoft is hosting an Inside Xbox event on April 16th and this may be where the company announces the new hardware. The rumour first gained traction when it was revealed by the perpetually reliable Thurrott in November past year .

Afghanisan: Taliban claim attack as spring offensive begins
Qais Mangal, a spokesman for the Afghan Ministry of Defence, dismissed the Taliban's spring offensive as "mere propaganda". The Taliban also called on fighters to avoid civilian deaths in their attacks.