Chinese researchers produce mouse pups with same-sex parents

The bimaternal mice offspring- born to two mothers- later produced pups of their own

In the case of the female mice, three "imprinting regions" were deleted from the stem cells, which were then injected into the eggs of another mouse.

Chinese scientists have created healthy baby mice with two mothers and no father, pushing back the barriers to same-sex reproduction in humans. The mice were normal, lived to adulthood, and went on to have babies of their own.

A scientist holds a healthy adult mouse born from two mothers.

Some reptiles, amphibians, and fish, however, have the benefit of parthenogenesis: a natural form of asexual reproduction in which growth and development of embryos occur without fertilization.

Making mice from two fathers was more complicated, the researchers said, and involved modifying haploid ESCs containing only a male parent's DNA. Mice produced from two fathers only survived a couple of days after being born.

Zhou said the key to producing healthy, normal mice was using a type of stem cell that contained one copy of DNA, instead of immature eggs seen in similar studies in the past.

A team of researchers has produced viable offspring from same-sex pairs of mice, using a novel technology that involves stem cells altered to remove certain genes.

Co-senior author Qi Zhou, Ph.D. professor at the State Key Laboratory of Stem Cell and Reproductive Biology at the Chinese Academy of Sciences in Beijing, China says, "We were interested in the question of why mammals can only undergo sexual reproduction". For example, there is a need to identify problematic imprinted genes that are unique to each species and ongoing concerns for the offspring that don't survive or that experience severe abnormalities.

"We found in this study that haploid ESCs were more similar to primordial germ cells, the precursors of eggs and sperm", said Baoyang Hu, another researcher.

Facebook Says Fewer Users Impacted by Recent Cyberattack than First Thought
However it also said that the total number of users affected by the incident was smaller than initially assumed. Facebook has said it will not provide identity fraud protection for the victims of its latest data breach.

Thinking About A New Phone? Get Ready For A Sticker Shock
If you were planning to trade your old Pixel handset just because of those features, it would be wise to wait a few weeks. Both phones still come with a single-lens rear camera system, but it doesn't sound like Google needs more than one lens.

Watch Hillary Tell Liberals To Abandon Civility Until They Retake Congress
While Heitkamp stands by her decision, her opposition to Kavanaugh may not help her re-election bid in North Dakota. Clinton took to Twitter to respond .

The nucleus of the mouse egg was removed, meaning there was no female genetic material left and the fertilised egg was placed in a surrogate mouse.

They used a special kind of stem cell called a "haploid" embryonic stem cell, which means that they contain 23 rather than the usual 46 DNA-carrying chromosomes (just like male sperm).

The study, published on Thursday in Cell Stem Cell journal, is the first time the method has been successfully implemented, though previous research has looked at other ways to produce babies from same-sex pairs.

However, the method presents ethical and practical hurdles if this technology were to ever be considered for humans, the researchers said.

Both included half the DNA needed to make a new pup, but it wasn't quite that simple.

Wei Li, Ph.D., a co-senior author on the study, notes that there are still obstacles to using these methods in other mammals.

The researchers aren't entirely sure why this happened, although they are planning to develop their procedures and try again in the future.

"We saw that the defects in bimaternal mice can be eliminated and that bipaternal reproduction barriers in mammals can also be crossed through imprinting modification". "However, the generated mice still showed defective features, and the method itself is very impractical and hard to use", said Zhou.

Related News:



Most liked

Astronauts Make Emergency Landing in Failed Russian Space Launch
The two crew members on board, cosmonaut Alexey Ovchinin and Nick Hague of NASA, are alive after performing an emergency landing. They all were scheduled to return to Earth in mid-December, but may have to stay aboard the station longer.

Angelo Mathews is Sri Lanka’s Best Batsman - Dinesh Chandimal
He added that they have been playing well and further told that they are very aware of Sri Lanka's quality in home conditions. Captain Angelo Mathews has been replaced by Dinesh Chandimal for the hosts, who were disappointing in the recent Asia Cup .

Under water: How rising waters cost us all
Droughts and food shortages will likely increase as well, leading to conflicts and heightened levels of terrorism. Half a degree less of warming could even save some of the world's coral reefs.

Michael, Now Post-Tropical Storm, Batters Tri-State With Rain, Wind
Monster Hurricane Michael has now moved out into the Atlantic, but it left behind devastation of catastrophic proportions. Brock Long, head of the Federal Emergency Management Agency (FEMA), warned that he expected the number of deaths to rise.

Croatia hold wasteful England in empty stadium
And six minutes after the break Kane rose highest to a Henderson free-kick only to see his looping header come back off the crossbar.

Passengers Ready For World's Longest Flight
There are also hospital-grade HEPA filters circulating air throughout the entire cabin every two to three minutes. Business class one-way fares start at $3,379 from Newark to Singapore later this month, or $5,098 round-trip.

Parkour-loving Atlas robot can now run and jump over obstacles
Atlas looks so much like a mechanized super solider that someone at The Verge had this bright idea for it: Robot Ninja Warrior. Boston Dynamics calls the robot "the world's most dynamic humanoid" and it weighs 75 kilograms, or about 165 pounds.

Bodies of 11 infants found in ceiling of shuttered Detroit funeral home
In April state inspectors found decomposing bodies in an non-refrigerated garage and a back room of the home, WDIV reported . The bodies of 11 infants were discovered at the shuttered Cantrell Funeral Home in Detroit on Friday, Oct. 12, 2018.

Didi Gregorius Injury: Yankees Shortstop To Undergo Tommy John Surgery
On the season, Gregorius hit.268, with 27 homers and 86 RBI and was one of the key sluggers in the lineup. The New York Yankees didn't just lose their American League Division Series against the Boston Red Sox .

Senate deal confirms 15 more Trump judges
Trump didn't help by apologising to Kavanaugh and his family for their "pain and suffering", says Jennifer Rubin in the Washington Post .

Braves season ends in Gm. 4, Dodgers advance 6-2
Coming off a tense victory in Game 3, the Baby Braves grabbed the lead on pinch-hitter Kurt Suzuki's two-run single in the fourth. Game 3 of the NLDS between the Dodgers and Braves has a scheduled first pitch today at 8:07 pm EST / 5:07 pm PST.

Astronauts make emergency landing after Soyuz rocket failure
Glitches found in Russia's Proton and Soyuz rockets in 2016 were traced to manufacturing flaws at the plant in Voronezh. The Russian space agency Roscosmos tweeted that it's creating a formal commission to investigate the rocket failure.

Fallout 76 might not get mod support before November 2019
You can check out the full map below for Fallout 76 which will be heading to PlayStation 4, Xbox One and PC on 14th November. If you thought West Virginia would be upset about being portrayed as a nuclear wasteland in Fallout 76, you'd be dead wrong.

Paul George explains why he's on Jimmy Butler's side
The medicals were exchanged, which, really, generally in the National Basketball Association means this is a done deal. Thibodeau told reporters he did expect Butler to end his holdout and show up for the practice.

No-deal Brexit would wipe out trade deals with 70 countries
The UK government are drawing up secret plans to extend the transition period in the Brexit withdrawal agreement, according to reports.